Idebenone CAS 58186-27-9

Idebenone is an organic compound with the chemical name: 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone. It is a structural analogue of coenzyme Q10 and is developed by Takeda Pharmaceuticals as a drug for the treatment of cognitive diseases such as Alzheimer’s disease.

Idebenone has an activating effect on mitochondrial function, improves brain metabolism and brain dysfunction, and can increase the utilization rate of glucose in the brain and promote the generation of ATP; it improves the metabolism of the neurotransmitter 5-hydroxytryptamine in the brain and has a strong antioxidant and free radical scavenging effect. In clinical practice, it is mainly used to treat many central nervous system degenerative diseases related to oxidative stress, such as Parkinson’s disease, Alzheimer’s disease, multi-infarct dementia, local cerebral anemia and brain failure, etc. It is also used to treat Friedreich’s ataxia. It can also be used in cosmetic formulas, with cosmetic efficacy such as scavenging free radicals, inhibiting lipid peroxidation, inhibiting inflammation, inhibiting DNA damage, light protection, and reducing pigmentation.

Idebenone CAS 58186-27-9

Idebenone Basic information
Product Name: Idebenone
Synonyms: cv 2619 idebenone;Daruma:Mnesis;2,5-Cyclohexadiene-1,4-dione, 5,6-dimethoxy-2-(10-hydroxydecyl)-3-methyl-;6-(10-Hydroxydecyl)ubiquinone;2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione;2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone;IDEBENONE(P);2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadienPl,4-dione
CAS: 58186-27-9
MF: C19H30O5
MW: 338.44
EINECS: 1308068-626-2
Product Categories: Aromatics;API;Other APIs;AP;Anthraquinones, Hydroquinones and Quinones;Cnbio;Intermediates & Fine Chemicals;Pharmaceuticals;58186-27-9
Mol File: 58186-27-9.mol
Idebenone Structure
Idebenone Chemical Properties
Melting point 52-550C
Boiling point 497.3±45.0 °C(Predicted)
density 1.08±0.1 g/cm3(Predicted)
storage temp. room temp
solubility Soluble in DMSO (up to 25 mg/ml).
form Solid
pka 15.20±0.10(Predicted)
color Orange
Merck 14,4888
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
InChIKey JGPMMRGNQUBGND-UHFFFAOYSA-N
SMILES C1(=O)C(OC)=C(OC)C(=O)C(C)=C1CCCCCCCCCCO
LogP 3.490 (est)
CAS DataBase Reference 58186-27-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
WGK Germany 3
RTECS GU5290000
HS Code 2933399990