L-Epicatechin CAS # 490-46-0

L-Epicatechin is a polyketide synthase-derived polyphenol flavonoid that has been observed in T. cacao and has numerous organic activities. It scavenges DPPH radicals in a cell-free assay when used at a attention of 5 μM. (−)-Epicatechin inhibits COX-1 (IC50 = 3.2 μM). It acts synergistically with epigallocatechin gallate to result in apoptosis in, and decrease the proliferation of, PC-9 lung most cancers cells when used at a awareness of 200 μM. (−)-Epicatechin (80 mg/kg) reduces LPS-induced will increase in plasma creatinine and urea ranges in a rat mannequin of renal inflammation.

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L-Epicatechin CAS # 490-46-0

 

Product Name: L-Epicatechin
Synonyms: 3,3′,4′,5,7-PENTAHYDROXY-FLAVANE;3,3′,4′,5,7-PENTAHYROXYFLAVONE;3,3′,4′,5,7-PENTAHYDROXYFLAVAN;(-)-epicatecho;(-)-epicatechol;(+)-EPICATECHIN;EPICATECHIN, (+)-;CIS-2-[3,4-DIHYDROXYPHENYL]-3,4-DIHYDRO-2H-1-BENZOPYRAN-3,5,7-TRIOL
CAS: 490-46-0
MF: C15H14O6
MW: 290.27
EINECS: 207-710-1
Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Pharmaceutical Raw Materials;Aromatics;Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;chiral;490-46-0
Mol File: 490-46-0.mol
L-Epicatechin Structure
L-Epicatechin Chemical Properties
Melting point 240 °C (dec.)(lit.)
alpha -55~-65゜(D/20℃)(c=1,CH3OH)
Boiling point 629.2 °C
density 1.593±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥14.5 mg/mL in DMSO
form Solid
pka 9.54±0.10(Predicted)
color White to Light yellow to Light orange
Water Solubility Soluble in water or alcohol
Merck 13,1912
BRN 92760
Stability: Hygroscopic
InChIKey PFTAWBLQPZVEMU-UKRRQHHQSA-N
LogP 0.490 (est)
CAS DataBase Reference 490-46-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS KB3745000
F 10-23
HS Code 29329990