2-Phenoxyethanol CAS#122-99-6

2-Phenoxyethanol, also known as ethylene glycol phenyl ether, is a widely used ingredient in the cosmetics and pharmaceutical industries, primarily recognized for its preservative properties. With the chemical formula C8H10O2, this organic compound is effective in preventing microbial growth, ensuring the safety and stability of formulations.

As a para-hydroxybenzoate (parabens alternative), 2-phenoxyethanol is appreciated for its broad-spectrum antimicrobial activity, which includes the inhibition of both gram-positive and gram-negative bacteria, as well as yeast and mold. It is commonly used in concentrations ranging from 0.5% to 2% to provide adequate preservation without impacting the product’s sensory profile.

This colorless liquid is soluble in water and most organic solvents, making it compatible with a variety of formulations. Its low order of toxicity and minimal skin irritation potential at prescribed concentrations contribute to its favorable safety profile.

In summary, 2-phenoxyethanol is a reliable and efficient preservative for a diverse range of cosmetic products, offering broad-spectrum protection against microbial contamination while maintaining product integrity and consumer safety. Its use is critical in upholding the quality and longevity of personal care products.

2-Phenoxyethanol Chemical Properties
Melting point 11-13 °C (lit.)
Boiling point 247 °C (lit.)
density 1.102 g/mL at 25 °C (lit.)
vapor density 4.8 (vs air)
vapor pressure 0.01 mm Hg ( 20 °C)
FEMA 4620 | 2-PHENOXYETHANOL
refractive index n20/D 1.539
Fp >230 °F
storage temp. Store below +30°C.
solubility soluble, clear, colorless to very faintly yellow
pka 14.36±0.10(Predicted)
form Liquid
Specific Gravity 1.109 (20/4℃)
color Clear colorless
Odor Faint aromatic odor
PH Range 7 at 10 g/l at 23 °C
PH 7 (10g/l, H2O, 23℃)
explosive limit 1.4-9.0%(V)
Odor Type floral
Water Solubility 30 g/L (20 ºC)
Merck 14,7257
BRN 1364011
InChIKey QCDWFXQBSFUVSP-UHFFFAOYSA-N
LogP 1.2 at 23℃
CAS DataBase Reference 122-99-6(CAS DataBase Reference)
NIST Chemistry Reference 2-Phenoxyethanol(122-99-6)
EPA Substance Registry System Ethylene glycol monophenyl ether (122-99-6)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36-R36-R22
Safety Statements 26-S26
WGK Germany 1
RTECS KM0350000
Autoignition Temperature 535 °C DIN 51794
Hazard Note Irritant
TSCA Yes
HS Code 29094990
Hazardous Substances Data 122-99-6(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 1850 mg/kg LD50 dermal Rabbit > 2000 mg/kg