2-Methyl-4-isothiazolin-3-one CAS#2682-20-4

2-Methyl-4-isothiazolin-3-one, commonly referred to as MI, is a potent, synthetic preservative widely used in the cosmetic and personal care industry. This organic compound, with the chemical formula C4H5NOS, is a member of the isothiazolinone family known for its broad-spectrum antimicrobial activity.

MI is effective against a variety of microorganisms, including bacteria, yeasts, and molds, making it an ideal preservative for formulations that require protection from spoilage and contamination. It is particularly valued for its ability to provide long-lasting protection even at low concentrations.

As a preservative, MI is recognized for its compatibility with a wide range of cosmetic ingredients and its ability to be used in leave-on and rinse-off products. Its stability in different pH ranges and resistance to heat and light further contribute to its utility in various formulations.

In summary, 2-Methyl-4-isothiazolin-3-one is a reliable and efficient preservative, offering robust antimicrobial protection for a diverse array of products. Its versatility and effectiveness make it a preferred choice for maintaining the integrity and safety of cosmetic and personal care products.

2-Methyl-4-isothiazolin-3-one Chemical Properties
Melting point 254-256 °C(lit.)
Boiling point bp0.03 93°
density 1.25 (14% aq.)
vapor pressure <0.1 mm Hg ( 25 °C)
storage temp. 2-8°C
solubility Chloroform, Ethyl Acetate
pka -2.03±0.20(Predicted)
form Solid
color Yellow
Water Solubility 489g/L at 20℃
BRN 606203
InChIKey BEGLCMHJXHIJLR-UHFFFAOYSA-N
LogP -0.486 at 20℃
CAS DataBase Reference 2682-20-4(CAS DataBase Reference)
NIST Chemistry Reference 3(2H)-isothiazolone, 2-methyl-(2682-20-4)
EPA Substance Registry System 2-Methyl-3(2H)-isothiazolone (2682-20-4)
Safety Information
Hazard Codes N,C,T
Risk Statements 50/53-50-43-34-20/21/22-37-23-22
Safety Statements 60-61-36/37/39-26-24-45
RIDADR UN 3077 9/PG 3
WGK Germany 2
RTECS FE1250000
HazardClass 8
PackingGroup III
HS Code 29349990
Hazardous Substances Data 2682-20-4(Hazardous Substances Data)