Ursolic Acid CAS# 77-52-1

Ursolic acid (UA, 77-52-1) (3β-hydroxy-urso-12-ene-28-fatty acid) is a pentacyclic triterpene carboxylic acid compound (C30H48O3) that can exist in the free acid form or in the aglycone form of triterpene saponins. Its isomers, oleanolic acid (OA) (3β-hydroxy-oleo-12-ene-28-fatty acid), differ in the degree of methyl substitution but have similar molecular structures and pharmacological activities [1]. Oleanolic acid and ursolic acid are triterpenoids that are ubiquitous in the plant kingdom and medicinal herbs. Once found in fruits and herbs, they are an indispensable part of the human diet. Structure of ursolic acid
In recent years, they have been the subject of many publications due to their diverse activities and low toxicity. Ursolic acid has been reported to have a variety of beneficial effects, such as antioxidant, antimicrobial, anti-inflammatory, anticancer, antihyperlipidemic, analgesic, hepatoprotective, gastroprotective, antiulcer, anti-HIV, cardiovascular, anti-atherosclerotic and immunomodulatory effects [2, 3].

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Ursolic Acid CAS# 77-52-1

Product Name: Ursolic acid
Synonyms: 3BETA-HYDROXY-12-URSEN-28-OIC ACID;3B-HYDROXYURS-12-EN-28-OIC ACID;Ursolic acid 3beta-Hydroxyurs-12-en-28-oic acid;(1S,2R,4aS,6aS,6bR,12aR,12bR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid;(3beta)-urs-12-en-28-oicaci;3-hydroxy-,(3.beta.)-Urs-12-en-28-oicacid;URSOLIC ACID hplc;Urs-12-en-28-oic acid, 3-hydroxy-, (3)-
CAS: 77-52-1
MF: C30H48O3
MW: 456.7
EINECS: 201-034-0
Product Categories: Natural Plant Extract;natural product;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Intermediates & Fine Chemicals;Pharmaceuticals;chiral;Antineoplastic;oleanolic acid;Ursolic acid;Inhibitors;Triterpenoids;Plant extract;Organics;Tri-Terpenoids;Pentacyclic Triterpenes;77-52-1
Mol File: 77-52-1.mol
Ursolic acid Structure
Ursolic acid Chemical Properties
Melting point 292 °C (dec.) (lit.)
alpha 59 º (c=0.3, pyridine)
Boiling point 502.79°C (rough estimate)
density 1.0261 (rough estimate)
refractive index 1.4940 (estimate)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 25 mg/ml with warming)
form Crystalline Powder or Needles
pka 4.68±0.70(Predicted)
color White to off-white
optical activity +6620 (c 1.4, C5H5N)
Water Solubility insoluble
Merck 14,9890
BRN 2228563
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
LogP 8.731 (est)
CAS DataBase Reference 77-52-1(CAS DataBase Reference)
EPA Substance Registry System Urs-12-en-28-oic acid, 3-hydroxy-, (3.beta.)- (77-52-1)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-36-26
WGK Germany
RTECS YU9520000
F 10-23
HS Code 29181990
Hazardous Substances Data 77-52-1(Hazardous Substances Data)